Reactome | alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)

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alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) Show undefined attributes

catalystActivity	[CatalystActivity:10334480] L-glutamate dehydrogenase [NAD(P)+] activity of GLUD hexamer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10334482
displayName	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
eventOf	[Pathway:R-BTA-8964539] Glutamate and glutamine metabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Bos taurus
inferredFrom	[Reaction:R-HSA-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [DefinedSet:R-ALL-517496] NAD(P)H [mitochondrial matrix] [SimpleEntity:R-ALL-113561] NH4+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) 2-oxoglutarate + H(+) + NADH + NH4(+) => H2O + L-glutamate + NAD(+) 2-oxoglutarate + H(+) + NADPH + NH4(+) => H2O + L-glutamate + NADP(+)
output	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [DefinedSet:R-ALL-517495] NAD(P)+ [mitochondrial matrix]
regulatedBy	[Requirement:9986738] Requirement by 'ADP [mitochondrial matrix]' [NegativeRegulation:R-HSA-70591] Negative regulation by 'GTP [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-70589
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8964539] Glutamate and glutamine metabolism
(precedingEvent)	[Reaction:R-BTA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]
(inferredTo)	[Reaction:R-HSA-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)

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