Reactome | NUDT13 hydrolyses AP6A to AP4 and ADP

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NUDT13 hydrolyses AP6A to AP4 and ADP Show undefined attributes

catalystActivity	[CatalystActivity:10418277] pyrophosphatase activity of NUDT13 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10418279
displayName	NUDT13 hydrolyses AP6A to AP4 and ADP
eventOf	[Pathway:R-BTA-499943] Interconversion of nucleotide di- and triphosphates - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6810472] NUDT13 hydrolyses AP6A to AP4 and ADP - Homo sapiens
input	[SimpleEntity:R-ALL-6810468] AP6A [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	NUDT13 hydrolyses AP6A to AP4 and ADP P(1),P(6)-bis(5'-adenosyl) hexaphosphate + H2O => adenosine 5'-tetraphosphate + ADP + 2 H(+)
output	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-6810471] AP4 [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-6810472
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-499943] Interconversion of nucleotide di- and triphosphates
(inferredTo)	[Reaction:R-HSA-6810472] NUDT13 hydrolyses AP6A to AP4 and ADP

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