Reactome | GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)

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GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) Show undefined attributes

catalystActivity	[CatalystActivity:10343570] gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10416804
displayName	GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)
eventOf	[Pathway:R-BTA-159740] Gamma-carboxylation of protein precursors - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-6807229] Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus - Bos taurus [Reaction:R-BTA-159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) - Bos taurus
inferredFrom	[Reaction:R-HSA-6807214] GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-6807212] BGLAP(24-100) [endoplasmic reticulum lumen] 3 × [SimpleEntity:R-ALL-159751] CO2 [endoplasmic reticulum lumen] 3 × [SimpleEntity:R-ALL-6806362] MK4 [endoplasmic reticulum lumen] 3 × [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) pro-osteocalciin, uncarboxylated + 3 CO2 + 3 O2 + 3 vitamin K hydroquinone -> gamma-carboxylated pro-osteocalcin + 3 H2O + 3 vitamin K epoxide
output	[EntityWithAccessionedSequence:R-BTA-6807218] 3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen] 3 × [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] 3 × [SimpleEntity:R-ALL-6806366] MK4 epoxide [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-BTA-159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) - Bos taurus [Reaction:R-BTA-6806674] UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-6807214
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-159740] Gamma-carboxylation of protein precursors
(precedingEvent)	[BlackBoxEvent:R-BTA-6807229] Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus [Reaction:R-BTA-159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)
(inferredTo)	[Reaction:R-HSA-6807214] GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)

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