Reactome | S100A8:S100A9 binds Mn2+

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10412396
displayName	S100A8:S100A9 binds Mn2+
eventOf	[Pathway:R-BTA-6799990] Metal sequestration by antimicrobial proteins - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6798528] S100A8:S100A9 binds Mn2+ - Homo sapiens
input	2 × [SimpleEntity:R-ALL-266099] Mn2+ [extracellular region] 2 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region] [Complex:R-BTA-8944198] S100A8:S100A9:Ca2+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	S100A8:S100A9 binds Mn2+
output	[Complex:R-BTA-6798411] S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-6798528
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-6799990] Metal sequestration by antimicrobial proteins
(inferredTo)	[Reaction:R-HSA-6798528] S100A8:S100A9 binds Mn2+

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