Reactome | PP5 dephosphorylates RAF1 S338

Schema > Reaction > Entries

PP5 dephosphorylates RAF1 S338 Show undefined attributes

catalystActivity	[CatalystActivity:10404874] protein serine/threonine phosphatase activity of PPP5C [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10404876
displayName	PP5 dephosphorylates RAF1 S338
eventOf	[Pathway:R-BTA-5675221] Negative regulation of MAPK pathway - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5675431] PP2A dephosphorylates RAF1 - Bos taurus
inferredFrom	[Reaction:R-HSA-5675433] PP5 dephosphorylates RAF1 S338 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-BTA-5675414] p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PP5 dephosphorylates RAF1 S338
output	[Complex:R-BTA-5675430] p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5675433
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5675221] Negative regulation of MAPK pathway
(precedingEvent)	[Reaction:R-BTA-5675431] PP2A dephosphorylates RAF1
(inferredTo)	[Reaction:R-HSA-5675433] PP5 dephosphorylates RAF1 S338

Cite Us!