Reactome | BRCA1 forms a heterodimer with BARD1

Schema > Reaction > Entries

BRCA1 forms a heterodimer with BARD1 Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10403554
displayName	BRCA1 forms a heterodimer with BARD1
eventOf	[Pathway:R-BTA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9701003] BAP1 binds BRCA1:BARD1 heterodimer - Bos taurus [Reaction:R-BTA-9701000] BRCA1:BARD1 heterodimer autoubiquitinates - Bos taurus [Reaction:R-BTA-5683385] Formation of BRCA1-A complex at DNA DSBs - Bos taurus
inferredFrom	[Reaction:R-HSA-5659781] BRCA1 forms a heterodimer with BARD1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-5659775] BARD1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-50949] BRCA1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	BRCA1 forms a heterodimer with BARD1
output	[Complex:R-BTA-5659802] BRCA1:BARD1 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5659781
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-BTA-9701003] BAP1 binds BRCA1:BARD1 heterodimer [Reaction:R-BTA-5683385] Formation of BRCA1-A complex at DNA DSBs [Reaction:R-BTA-9701000] BRCA1:BARD1 heterodimer autoubiquitinates
(inferredTo)	[Reaction:R-HSA-5659781] BRCA1 forms a heterodimer with BARD1