Reactome | PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB

Schema > Reaction > Entries

PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB Show undefined attributes

category	dissociation
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10402789
displayName	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB
eventOf	[Pathway:R-BTA-110362] POLB-Dependent Long Patch Base Excision Repair - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5651828] PARG dePARylates PARP1,PARP2 - Bos taurus
inferredFrom	[Reaction:R-HSA-5651739] PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB - Homo sapiens
input	[Complex:R-BTA-5651725] PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB
output	[Complex:R-BTA-5651754] FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] [Complex:R-BTA-5651709] PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]
precedingEvent	[Reaction:R-BTA-5651723] PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5651739
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-110362] POLB-Dependent Long Patch Base Excision Repair
(precedingEvent)	[Reaction:R-BTA-5651828] PARG dePARylates PARP1,PARP2
(inferredTo)	[Reaction:R-HSA-5651739] PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB

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