Reactome | POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-BTA-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Bos taurus [Reaction:R-BTA-110364] PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10340523
displayName	POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-BTA-50119] APEX1 [nucleoplasm] [GenomeEncodedEntity:R-BTA-5649881] Ghost homologue of SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-53845] POLB [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5649885] POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] - Homo sapiens
maxDepth	2
name	POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA
producedByEvent	[Reaction:R-BTA-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-5649885
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-BTA-110364] PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 [Reaction:R-BTA-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
(output)	[Reaction:R-BTA-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site
(inferredTo)	[Complex:R-HSA-5649885] POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]

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