Reactome | NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10402657] polynucleotide 3'-phosphatase activity of NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-BTA-5649705] PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10402654
displayName	NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm]
hasComponent	[Complex:R-BTA-110338] LIG3:XRCC1 [nucleoplasm] [Complex:R-BTA-5649730] NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5649651] PNKP [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5649729] NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] - Homo sapiens
maxDepth	4
name	NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA
producedByEvent	[Reaction:R-BTA-5649726] LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-5649729
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-BTA-5649705] PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)
(physicalEntity)	[CatalystActivity:10402657] polynucleotide 3'-phosphatase activity of NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm]
(output)	[Reaction:R-BTA-5649726] LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA
(inferredTo)	[Complex:R-HSA-5649729] NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm]

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