Reactome | Activated protein C cleaves factor VIIIa

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Activated protein C cleaves factor VIIIa Show undefined attributes

catalystActivity	[CatalystActivity:10342415] serine-type endopeptidase activity of Activated protein C:Protein S [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10400504
displayName	Activated protein C cleaves factor VIIIa
eventOf	[Pathway:R-BTA-9769739] Regulation of clotting cascade - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5607002] Activated protein C cleaves factor VIIIa - Homo sapiens
input	[Complex:R-BTA-158307] factor VIIIa [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated protein C cleaves factor VIIIa
output	[EntityWithAccessionedSequence:R-BTA-5606999] F8 [extracellular region] [EntityWithAccessionedSequence:R-BTA-5607008] F8 [extracellular region] [Complex:R-BTA-5607059] Inactivated factor VIII [extracellular region]
regulatedBy	[PositiveRegulation:10400505] Positive regulation by 'factor V [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5607002
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9769739] Regulation of clotting cascade
(inferredTo)	[Reaction:R-HSA-5607002] Activated protein C cleaves factor VIIIa

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