Reactome | Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa)

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Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10400405
displayName	Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa)
eventOf	[Pathway:R-BTA-9769739] Regulation of clotting cascade - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5578883] Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) - Homo sapiens
input	[Complex:R-BTA-156786] activated thrombin (factor IIa) [extracellular region] [EntityWithAccessionedSequence:R-BTA-5578885] SERPIND1 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) SERPIND1 binds activated thrombin (factor IIa)
output	[Complex:R-BTA-5578881] activated thrombin (factor IIa):SERPIND1 [extracellular region]
regulatedBy	[PositiveRegulation:R-HSA-5578890] Positive regulation by 'GAG [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5578883
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9769739] Regulation of clotting cascade
(inferredTo)	[Reaction:R-HSA-5578883] Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa)

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