Reactome | CYP1A2, 3A4 oxidise AFB1 to AFNBO

Schema > Reaction > Entries

CYP1A2, 3A4 oxidise AFB1 to AFNBO Show undefined attributes

catalystActivity	[CatalystActivity:10400112] monooxygenase activity of CYP1A2,3A4 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10400114
displayName	CYP1A2, 3A4 oxidise AFB1 to AFNBO
eventOf	[Pathway:R-BTA-5423646] Aflatoxin activation and detoxification - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5423653] MGST trimers transfer GS from GSH to AFXBO and AFNBO - Bos taurus
inferredFrom	[Reaction:R-HSA-5423672] CYP1A2, 3A4 oxidise AFB1 to AFNBO - Homo sapiens
input	[SimpleEntity:R-ALL-5423605] AFB1 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP1A2, 3A4 oxidise AFB1 to AFNBO
output	[SimpleEntity:R-ALL-5423663] AFNBO [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5423672
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5423646] Aflatoxin activation and detoxification
(precedingEvent)	[Reaction:R-BTA-5423653] MGST trimers transfer GS from GSH to AFXBO and AFNBO
(inferredTo)	[Reaction:R-HSA-5423672] CYP1A2, 3A4 oxidise AFB1 to AFNBO