Reactome | CYGB dioxygenates NO

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CYGB dioxygenates NO Show undefined attributes

catalystActivity	[CatalystActivity:10399240] nitric oxide dioxygenase activity, heme protein as donor of CYGB(Fe2+) dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10399242
displayName	CYGB dioxygenates NO
eventOf	[Pathway:R-BTA-203615] eNOS activation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5340226] CYGB dioxygenates NO - Homo sapiens
input	[Complex:R-BTA-5340240] CYGB(Fe2+) dimer [cytosol] [SimpleEntity:R-ALL-202124] NO [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYGB dioxygenates NO Fe(II)-heme b-(protein) + nitric oxide + O2 => Fe(III)-heme b-(protein) + nitrate
output	[Complex:R-BTA-9911162] CYBG(Fe3+) dimer [cytosol] [SimpleEntity:R-ALL-432031] NO3- [cytosol]
precedingEvent	[Reaction:R-BTA-5340214] CYGB binds O2 - Bos taurus
regulatedBy	[PositiveRegulation:9911142] Positive regulation by 'AscH- [cytosol]' [PositiveRegulation:10399243] Positive regulation by 'CYB5B [endoplasmic reticulum membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5340226
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-203615] eNOS activation
(inferredTo)	[Reaction:R-HSA-5340226] CYGB dioxygenates NO

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