Reactome | SRC-1 phosphorylates p-Y397-PTK2

Schema > Reaction > Entries

SRC-1 phosphorylates p-Y397-PTK2 Show undefined attributes

catalystActivity	[CatalystActivity:10397940] protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10397942
displayName	SRC-1 phosphorylates p-Y397-PTK2
eventOf	[Pathway:R-BTA-4420097] VEGFA-VEGFR2 Pathway - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5218643] HSP90AA1 binds p-6Y-VEGFR2 - Bos taurus
inferredFrom	[Reaction:R-HSA-5218640] SRC-1 phosphorylates p-Y397-PTK2 - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-5218641] VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SRC-1 phosphorylates p-Y397-PTK2
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-5218636] VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane]
precedingEvent	[Reaction:R-BTA-5218645] SRC-1 binds p-Y397-PTK2 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5218640
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-BTA-5218643] HSP90AA1 binds p-6Y-VEGFR2
(inferredTo)	[Reaction:R-HSA-5218640] SRC-1 phosphorylates p-Y397-PTK2

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