Reactome | Gab2 binds the p85 subunit of Class 1A PI3 kinases

Schema > Reaction > Entries

Gab2 binds the p85 subunit of Class 1A PI3 kinases Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10367927
displayName	Gab2 binds the p85 subunit of Class 1A PI3 kinases
eventOf	[Pathway:R-BTA-912526] Interleukin receptor SHC signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Homo sapiens
input	[DefinedSet:R-BTA-912533] Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] 4 × [DefinedSet:R-BTA-508248] p85-containing Class 1A PI3Ks [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Gab2 binds the p85 subunit of Class 1A PI3 kinases
output	[DefinedSet:R-BTA-912535] Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane]
precedingEvent	[BlackBoxEvent:R-BTA-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-508247
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-912526] Interleukin receptor SHC signaling
(inferredTo)	[Reaction:R-HSA-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases

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