Reactome | RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)

Schema > BlackBoxEvent > Entries

RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) Show undefined attributes

catalystActivity	[CatalystActivity:10392043] SUMO transferase activity of PIAS3 [nucleoplasm] [CatalystActivity:10396592] SUMO transferase activity of RANBP2:RANGAP1-SUMO1:UBE2I:Nuclear Pore Complex (NPC) [nuclear envelope]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10396594
displayName	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)
eventOf	[Pathway:R-BTA-4615885] SUMOylation of DNA replication proteins - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:4162] protein sumoylation
inferredFrom	[BlackBoxEvent:R-HSA-4655355] RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) - Homo sapiens
input	[Complex:R-BTA-4655348] Chromosome passenger complex [nucleoplasm] 2 × [DefinedSet:R-BTA-3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)
output	[Complex:R-BTA-4655354] SUMO2,3:Chromosome passenger complex [cytosol] 4 × [EntityWithAccessionedSequence:R-BTA-4655342] UBE2I [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-4655355
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-4615885] SUMOylation of DNA replication proteins
(inferredTo)	[BlackBoxEvent:R-HSA-4655355] RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)

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