Reactome | Phosphorylation of cPLA2 by MAPK p38 alpha

Schema > Reaction > Entries

Phosphorylation of cPLA2 by MAPK p38 alpha Show undefined attributes

catalystActivity	[CatalystActivity:10363811] protein serine/threonine kinase activity of p-T180,Y182-MAPK14 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10363813
displayName	Phosphorylation of cPLA2 by MAPK p38 alpha
eventOf	[Pathway:R-BTA-432142] Platelet sensitization by LDL - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase - Bos taurus
inferredFrom	[Reaction:R-HSA-428961] Phosphorylation of cPLA2 by MAPK p38 alpha - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-BTA-378502] PLA2G4A [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of cPLA2 by MAPK p38 alpha
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-BTA-111859] phospho-p-S505,S727-PLA2G4A [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-BTA-428941] P2Y purinoceptor 1 activates MAP kinase p38 alpha - Bos taurus [BlackBoxEvent:R-BTA-432148] Fgr may phosphorylate p38 MAPK - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-428961
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-432142] Platelet sensitization by LDL [Pathway:R-BTA-418592] ADP signalling through P2Y purinoceptor 1
(precedingEvent)	[Reaction:R-BTA-111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase
(inferredTo)	[Reaction:R-HSA-428961] Phosphorylation of cPLA2 by MAPK p38 alpha