Reactome | ACER3 hydrolyzes phytoceramide

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ACER3 hydrolyzes phytoceramide Show undefined attributes

catalystActivity	[CatalystActivity:10363678] N-acylsphingosine amidohydrolase activity of ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10363680
displayName	ACER3 hydrolyzes phytoceramide
eventOf	[Pathway:R-BTA-9845614] Sphingolipid catabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-428262] ACER3 hydrolyzes phytoceramide - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-9843855] phytoceramide-C16 [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ACER3 hydrolyzes phytoceramide phytoceramide + H2O => fatty acid + phytosphingosine
output	[SimpleEntity:R-ALL-428237] phytosphingosine [cytosol] [SimpleEntity:R-ALL-1861754] RCOO- [cytosol]
precedingEvent	[Reaction:R-BTA-428260] DEGS2 oxygenates dihydroceramide - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-428262
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9845614] Sphingolipid catabolism
(inferredTo)	[Reaction:R-HSA-428262] ACER3 hydrolyzes phytoceramide

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