Reactome | ACER1 hydrolyzes ceramide (endoplasmic reticulum)

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ACER1 hydrolyzes ceramide (endoplasmic reticulum) Show undefined attributes

catalystActivity	[CatalystActivity:10363647] N-acylsphingosine amidohydrolase activity of ACER1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10363649
displayName	ACER1 hydrolyzes ceramide (endoplasmic reticulum)
eventOf	[Pathway:R-BTA-9845614] Sphingolipid catabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9695949] SPHK2 phosphorylates sphingoid - Bos taurus [Reaction:R-BTA-428273] SPHK1 phosphorylates sphingoid - Bos taurus
inferredFrom	[Reaction:R-HSA-428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) - Homo sapiens
input	[SimpleEntity:R-ALL-428256] CERA [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ACER1 hydrolyzes ceramide (endoplasmic reticulum) ceramide + H2O <=> fatty acid + sphingosine (endoplasmic reticulum)
output	[SimpleEntity:R-ALL-1861754] RCOO- [cytosol] [SimpleEntity:R-ALL-428682] SPG [cytosol]
precedingEvent	[Reaction:R-BTA-428259] DEGS1 dehydrogenates dihydroceramide - Bos taurus [Reaction:R-BTA-1606288] SMPD4 hydrolyzes sphingomyelin (ER membrane) - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-428231
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9845614] Sphingolipid catabolism
(precedingEvent)	[Reaction:R-BTA-9695949] SPHK2 phosphorylates sphingoid [Reaction:R-BTA-428273] SPHK1 phosphorylates sphingoid
(inferredTo)	[Reaction:R-HSA-428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum)

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