Reactome | SIRT1 negatively regulates rRNA expression

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SIRT1 negatively regulates rRNA expression Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444594
displayName	SIRT1 negatively regulates rRNA expression
eventOf	[Pathway:R-BTA-5250941] Negative epigenetic regulation of rRNA expression - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21778] rDNA heterochromatin formation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-427528] Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) - Bos taurus [Reaction:R-BTA-427514] eNoSC deacetylates histone H3 - Bos taurus [Reaction:R-BTA-427527] eNoSC dimethylates histone H3 at lysine-9 - Bos taurus
inferredFrom	[Pathway:R-HSA-427359] SIRT1 negatively regulates rRNA expression - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SIRT1 negatively regulates rRNA expression Regulation of rRNA Expression by NAD-dependent Deacetylase Sirtuin-1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-427359
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5250941] Negative epigenetic regulation of rRNA expression
(inferredTo)	[Pathway:R-HSA-427359] SIRT1 negatively regulates rRNA expression

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