Reactome | SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol

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SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10363222] sodium:potassium:chloride symporter activity of SLC12A1,2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10363224
displayName	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol
eventOf	[Pathway:R-BTA-426117] Cation-coupled Chloride cotransporters - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-426086] SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol - Homo sapiens
input	2 × [SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-74126] K+ [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol Na+, K+/2Cl- cotransport
output	2 × [SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-29804] K+ [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-426086
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-426117] Cation-coupled Chloride cotransporters
(inferredTo)	[Reaction:R-HSA-426086] SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol

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