Reactome | F2R binds ARRB2

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F2R binds ARRB2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10361951
displayName	F2R binds ARRB2
eventOf	[Pathway:R-BTA-456926] Thrombin signalling through proteinase activated receptors (PARs) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-418176] F2R:ARRB2 binds MAPKs, SRC-1 - Bos taurus
inferredFrom	[Reaction:R-HSA-418172] F2R binds ARRB2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-416464] ARRB2 [cytosol] [EntityWithAccessionedSequence:R-BTA-114531] F2R [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	F2R binds ARRB2 Activated PAR1 binds beta-arrestin-2
output	[Complex:R-BTA-418167] F2R:ARRB2 [plasma membrane]
precedingEvent	[Reaction:R-BTA-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-418172
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-456926] Thrombin signalling through proteinase activated receptors (PARs)
(precedingEvent)	[Reaction:R-BTA-418176] F2R:ARRB2 binds MAPKs, SRC-1
(inferredTo)	[Reaction:R-HSA-418172] F2R binds ARRB2

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