Reactome | SOS binds Grb2 bound to pFAK:NCAM1

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SOS binds Grb2 bound to pFAK:NCAM1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10361135
displayName	SOS binds Grb2 bound to pFAK:NCAM1
eventOf	[Pathway:R-BTA-375165] NCAM signaling for neurite out-growth - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Bos taurus [Reaction:R-BTA-5672965] RAS GEFs promote RAS nucleotide exchange - Bos taurus
inferredFrom	[Reaction:R-HSA-392053] SOS binds Grb2 bound to pFAK:NCAM1 - Homo sapiens
input	[Complex:R-BTA-392047] Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] [EntityWithAccessionedSequence:R-BTA-64847] SOS1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SOS binds Grb2 bound to pFAK:NCAM1
output	[Complex:R-BTA-392045] Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane]
precedingEvent	[Reaction:R-BTA-392051] Recruitment of Grb2 to pFAK:NCAM1 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-392053
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-375165] NCAM signaling for neurite out-growth
(precedingEvent)	[Reaction:R-BTA-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras [Reaction:R-BTA-5672965] RAS GEFs promote RAS nucleotide exchange
(inferredTo)	[Reaction:R-HSA-392053] SOS binds Grb2 bound to pFAK:NCAM1