Reactome | HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA

Schema > Reaction > Entries

HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10360652] 3-hydroxyacyl-CoA dehydratase activity of HSD17B4 dimer [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10360669
displayName	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA
eventOf	[Pathway:R-BTA-390247] Beta-oxidation of very long chain fatty acids - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA - Bos taurus
inferredFrom	[Reaction:R-HSA-390252] HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-141343] H2O [peroxisomal matrix] [SimpleEntity:R-ALL-390249] trans-2,3-dehydrohexacosanoyl-CoA [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (2E)-hexacosenoyl-CoA + H2O => (3R)-hydroxyhexacosanoyl-CoA trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA
output	[SimpleEntity:R-ALL-390248] 3-hydroxyhexacosanoyl-CoA [peroxisomal matrix]
precedingEvent	[Reaction:R-BTA-390256] ACOX1 oxidizes C26:0 CoA - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-390252
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-390247] Beta-oxidation of very long chain fatty acids
(precedingEvent)	[Reaction:R-BTA-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA
(inferredTo)	[Reaction:R-HSA-390252] HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA

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