Reactome | ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix

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ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix Show undefined attributes

catalystActivity	[CatalystActivity:10360128] long-chain fatty acid transmembrane transporter activity of ABCD1-3 dimers [peroxisomal membrane]
category	transition
compartment	[Compartment:17947] peroxisomal membrane [Compartment:70101] cytosol [Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10360130
displayName	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix
eventOf	[Pathway:R-BTA-1369062] ABC transporters in lipid homeostasis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-390427] 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate - Bos taurus
inferredFrom	[Reaction:R-HSA-382575] ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-8876730] LCFA(-) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-382571] LCFA [peroxisomal matrix] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-BTA-382613] PEX-19 docks ABCD1/D2/D3 to peroximal membrane - Bos taurus [Reaction:R-BTA-390425] FAR1 reduces PalmCoA to HXOL - Bos taurus [Reaction:R-BTA-390438] FAR2 reduces PalmCoA to HXOL - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-382575
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1369062] ABC transporters in lipid homeostasis
(precedingEvent)	[Reaction:R-BTA-390427] 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate
(inferredTo)	[Reaction:R-HSA-382575] ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix

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