Reactome | IGFBP4 binds IGF forming IGF:IGFBP4

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IGFBP4 binds IGF forming IGF:IGFBP4 Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10359589
displayName	IGFBP4 binds IGF forming IGF:IGFBP4
eventOf	[Pathway:R-BTA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-381518] PAAP-A proteolyzes IGF:IGFBP4 - Bos taurus
inferredFrom	[Reaction:R-HSA-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Homo sapiens
input	[DefinedSet:R-BTA-381451] IGF1,2 [extracellular region] [EntityWithAccessionedSequence:R-BTA-381421] IGFBP4 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	IGFBP4 binds IGF forming IGF:IGFBP4
output	[Complex:R-BTA-381509] IGF:IGFBP4 [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-381543
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
(precedingEvent)	[Reaction:R-BTA-381518] PAAP-A proteolyzes IGF:IGFBP4
(inferredTo)	[Reaction:R-HSA-381543] IGFBP4 binds IGF forming IGF:IGFBP4

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