Reactome | PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O

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PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O Show undefined attributes

catalystActivity	[CatalystActivity:10393187] thioredoxin peroxidase activity of PRDX3,5 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10393189
displayName	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O
eventOf	[Pathway:R-BTA-3299685] Detoxification of Reactive Oxygen Species - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-3323050] TXNRD2 catalyzes the reduction of TXN2 by NADPH - Bos taurus
inferredFrom	[Reaction:R-HSA-3322995] PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O - Homo sapiens
input	[SimpleEntity:R-ALL-1614617] H2O2 [mitochondrial matrix] [EntityWithAccessionedSequence:R-BTA-3323048] TXN2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O
output	2 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [EntityWithAccessionedSequence:R-BTA-3323059] TXN2 [mitochondrial matrix]
precedingEvent	[Reaction:R-BTA-3323050] TXNRD2 catalyzes the reduction of TXN2 by NADPH - Bos taurus [Reaction:R-BTA-3299680] SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-3322995
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-3299685] Detoxification of Reactive Oxygen Species
(precedingEvent)	[Reaction:R-BTA-3323050] TXNRD2 catalyzes the reduction of TXN2 by NADPH
(inferredTo)	[Reaction:R-HSA-3322995] PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O

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