Reactome | CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1

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CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 Show undefined attributes

catalystActivity	[CatalystActivity:10392738] superoxide dismutase copper chaperone activity of CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10392740
displayName	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1
eventOf	[Pathway:R-BTA-3299685] Detoxification of Reactive Oxygen Species - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Bos taurus
inferredFrom	[Reaction:R-HSA-3299753] CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 - Homo sapiens
input	2 × [Complex:R-BTA-3299706] CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1
output	[Complex:R-BTA-3299679] 2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] [Complex:R-BTA-3299731] CCS:Zn2+:Cu1+ dimer [cytosol]
precedingEvent	[Reaction:R-BTA-8951723] 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-3299753
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-3299685] Detoxification of Reactive Oxygen Species
(precedingEvent)	[Reaction:R-BTA-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)
(inferredTo)	[Reaction:R-HSA-3299753] CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1

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