Reactome | CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77

Schema > Reaction > Entries

CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 Show undefined attributes

catalystActivity	[CatalystActivity:10391796] cyclin-dependent protein serine/threonine kinase regulator activity of CCND1:CDK4:PRMT5:WDR77 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10391798
displayName	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77
eventOf	[Pathway:R-BTA-3214858] RMTs methylate histone arginines - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5661117] CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 - Bos taurus [Reaction:R-BTA-3215426] COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 - Bos taurus [Reaction:R-BTA-5205799] CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) - Bos taurus
inferredFrom	[Reaction:R-HSA-3215385] CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 - Homo sapiens
input	[Complex:R-BTA-5205612] CCND1:CDK4:PRMT5:WDR77 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77
output	[Complex:R-BTA-5205604] CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-3215385
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-3214858] RMTs methylate histone arginines
(precedingEvent)	[Reaction:R-BTA-5661117] CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 [Reaction:R-BTA-3215426] COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 [Reaction:R-BTA-5205799] CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)
(inferredTo)	[Reaction:R-HSA-3215385] CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77