Reactome | MMACHC dealkylates RCbl

Schema > Reaction > Entries

MMACHC dealkylates RCbl Show undefined attributes

catalystActivity	[CatalystActivity:10391396] transferase activity, transferring alkyl or aryl (other than methyl) groups of MMACHC [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10391398
displayName	MMACHC dealkylates RCbl
eventOf	[Pathway:R-BTA-9759218] Cobalamin (Cbl) metabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Bos taurus
inferredFrom	[Reaction:R-HSA-3095889] MMACHC dealkylates RCbl - Homo sapiens
input	[SimpleEntity:R-ALL-29450] GSH [cytosol] [EntityWithAccessionedSequence:R-BTA-2980949] MMACHC [cytosol] [SimpleEntity:R-ALL-9759394] RCbl [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MMACHC dealkylates RCbl an R-cob(III)alamin + apo--(alkylcobalamin reductase) + glutathione => an S-substituted glutathione + cob(I)alamin--(alkylcobalamin reductase) + H(+)
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [Complex:R-BTA-9759561] MMACHC:cob(I)alamin [cytosol] [SimpleEntity:R-ALL-9759438] R-GSH [cytosol]
precedingEvent	[Reaction:R-BTA-9759206] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-3095889
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9759218] Cobalamin (Cbl) metabolism
(precedingEvent)	[BlackBoxEvent:R-BTA-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin
(inferredTo)	[Reaction:R-HSA-3095889] MMACHC dealkylates RCbl

Cite Us!