Reactome | Hydrolysis of internal thioester in C4b

Schema > Reaction > Entries

category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10390734
displayName	Hydrolysis of internal thioester in C4b
eventOf	[Pathway:R-BTA-977606] Regulation of Complement cascade - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2855047] Hydrolysis of internal thioester in C4b - Homo sapiens
input	[DefinedSet:R-BTA-981700] C4b [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Hydrolysis of internal thioester in C4b
output	[DefinedSet:R-BTA-2855046] C4b with hydrolysed thioester [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2855047
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-977606] Regulation of Complement cascade
(inferredTo)	[Reaction:R-HSA-2855047] Hydrolysis of internal thioester in C4b

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