Reactome | LTD4 is converted to LTE4 by DPEP1/2

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LTD4 is converted to LTE4 by DPEP1/2 Show undefined attributes

catalystActivity	[CatalystActivity:10355552] dipeptidase activity of DPEP1,2 dimers [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10355554
displayName	LTD4 is converted to LTE4 by DPEP1/2
eventOf	[Pathway:R-BTA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-266012] LTD4 is converted to LTE4 by DPEP1/2 - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [SimpleEntity:R-ALL-266074] LTD4 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	LTD4 is converted to LTE4 by DPEP1/2 H2O + leukotriene D4 => glycine + leukotriene E4 Further cleavage of LTD4 forms LTE4
output	[SimpleEntity:R-ALL-266029] Gly [extracellular region] [SimpleEntity:R-ALL-266033] LTE4 [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-266012
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
(inferredTo)	[Reaction:R-HSA-266012] LTD4 is converted to LTE4 by DPEP1/2

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