Reactome | Regulation of PLK1 Activity at G2/M Transition

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Regulation of PLK1 Activity at G2/M Transition Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10445274
displayName	Regulation of PLK1 Activity at G2/M Transition
eventOf	[Pathway:R-BTA-69275] G2/M Transition - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-2574845] AJUBA binds centrosome-associated AURKA - Bos taurus [Reaction:R-BTA-2574840] AJUBA facilitates AURKA autophosphorylation - Bos taurus [Reaction:R-BTA-4086410] CCNB:CDK1 phosphorylates BORA - Bos taurus [Reaction:R-BTA-3000319] BORA binds PLK1 and AURKA - Bos taurus [Reaction:R-BTA-3000310] AURKA phosphorylates PLK1 - Bos taurus [Reaction:R-BTA-3000327] PLK1 phosphorylates BORA - Bos taurus [Reaction:R-BTA-2562526] PLK1 phosphorylates OPTN - Bos taurus [Reaction:R-BTA-2562594] Phosphorylated OPTN translocates to the nucleus - Bos taurus [Reaction:R-BTA-3002798] Cytosolic PLK1 translocates to the nucleus - Bos taurus [Reaction:R-BTA-3002811] Myosin phosphatase dephosphorylates PLK1 - Bos taurus
inferredFrom	[Pathway:R-HSA-2565942] Regulation of PLK1 Activity at G2/M Transition - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of PLK1 Activity at G2/M Transition
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-2565942
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-69275] G2/M Transition
(inferredTo)	[Pathway:R-HSA-2565942] Regulation of PLK1 Activity at G2/M Transition

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