Reactome | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

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Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10443746
displayName	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
eventOf	[Pathway:R-BTA-170834] Signaling by TGF-beta Receptor Complex - Bos taurus [Pathway:R-BTA-212436] Generic Transcription Pathway - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5567] DNA-templated transcription
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-BTA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Bos taurus [Pathway:R-BTA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Bos taurus
inferredFrom	[Pathway:R-HSA-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-2173793
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-BTA-1502540] Signaling by Activin [Pathway:R-BTA-453279] Mitotic G1 phase and G1/S transition
(hasEvent)	[Pathway:R-BTA-212436] Generic Transcription Pathway [Pathway:R-BTA-170834] Signaling by TGF-beta Receptor Complex
(inferredTo)	[Pathway:R-HSA-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

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