Reactome | DIT and MIT combine to form triiodothyronine

Schema > Reaction > Entries

DIT and MIT combine to form triiodothyronine Show undefined attributes

catalystActivity	[CatalystActivity:10354054] halogenase activity of p-DUOX1,2:DUOXA1,2:TPO:CAV1:TXNDC11 [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10354156
displayName	DIT and MIT combine to form triiodothyronine
eventOf	[Pathway:R-BTA-209968] Thyroxine biosynthesis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-209925] DIT and MIT combine to form triiodothyronine - Homo sapiens
input	[SimpleEntity:R-ALL-352329] DIT [extracellular region] [SimpleEntity:R-ALL-351639] MIT [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	DIT and MIT combine to form triiodothyronine
output	[SimpleEntity:R-ALL-352036] L-Ala [extracellular region] [SimpleEntity:R-ALL-352331] T3 [extracellular region]
precedingEvent	[Reaction:R-BTA-209973] Tyrosine is diiodinated - Bos taurus [Reaction:R-BTA-209815] Tyrosine is monoiodinated - Bos taurus
regulatedBy	[PositiveRegulation:10354096] Positive regulation by 'Thyrotropin [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-209925
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-209968] Thyroxine biosynthesis
(inferredTo)	[Reaction:R-HSA-209925] DIT and MIT combine to form triiodothyronine

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