Reactome | CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]

catalystActivities	[CatalystActivity:10374873] protein serine/threonine kinase activity of Active IKK complex [cytosol] [CatalystActivity:10437182] protein serine/threonine kinase activity of CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] [CatalystActivity:10405775] IkappaB kinase activity of CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
compartment	[Compartment:70101] cytosol
consumedByEvent	[BlackBoxEvent:R-BTA-202534] Ubiquitination of NEMO by TRAF6 - Bos taurus [BlackBoxEvent:R-BTA-9758604] Ubiquitination of IKBKG by TRAF6 - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10352647
displayName	CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-BTA-168104] CHUK [cytosol] [EntityWithAccessionedSequence:R-BTA-168108] IKBKG [cytosol] [EntityWithAccessionedSequence:R-BTA-202506] phospho-p-S177,S181-IKBKB [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-727820] Active IKK complex [cytosol] - Homo sapiens [Complex:R-HSA-202513] CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] - Homo sapiens
maxDepth	2
name	CHUK:p-S177,S181-IKBKB:IKBKG
producedByEvent	[Reaction:R-BTA-202500] Activation of IKK complex - Bos taurus [Reaction:R-BTA-5607742] K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta - Bos taurus [Reaction:R-BTA-2730876] Phosphorylation of IKK-beta by TAK1 - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-202513
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(physicalEntity)	[CatalystActivity:10374873] protein serine/threonine kinase activity of Active IKK complex [cytosol] [CatalystActivity:10437182] protein serine/threonine kinase activity of CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] [CatalystActivity:10405775] IkappaB kinase activity of CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
(inferredTo)	[Complex:R-HSA-727820] Active IKK complex [cytosol] [Complex:R-HSA-202513] CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
(input)	[BlackBoxEvent:R-BTA-202534] Ubiquitination of NEMO by TRAF6 [BlackBoxEvent:R-BTA-9758604] Ubiquitination of IKBKG by TRAF6
(output)	[Reaction:R-BTA-5607742] K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta [Reaction:R-BTA-202500] Activation of IKK complex [Reaction:R-BTA-2730876] Phosphorylation of IKK-beta by TAK1

CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] Show undefined attributes

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