Reactome | Auto-ubiquitination of TRAF6

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Auto-ubiquitination of TRAF6 Show undefined attributes

catalystActivity	[CatalystActivity:10352624] ubiquitin-protein transferase activity of TRAF6 trimer bound to CBM complex [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10352626
displayName	Auto-ubiquitination of TRAF6
eventOf	[Pathway:R-BTA-202424] Downstream TCR signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-202510] Activation of TAK1-TAB2 complex - Bos taurus
inferredFrom	[Reaction:R-HSA-202453] Auto-ubiquitination of TRAF6 - Homo sapiens
input	3 × [Polymer:R-BTA-450152] K63polyUb [cytosol] [Complex:R-BTA-202471] TRAF6 trimer bound to CBM complex [plasma membrane] 3 × [Complex:R-BTA-202463] UBE2N:UBE2V1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Auto-ubiquitination of TRAF6
output	[Complex:R-BTA-202456] Ub-TRAF6 trimer bound to CBM complex [plasma membrane] 3 × [Complex:R-BTA-202463] UBE2N:UBE2V1 [cytosol]
precedingEvent	[Reaction:R-BTA-202472] Translocation of TRAF6 to CBM complex - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-202453
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-202424] Downstream TCR signaling
(precedingEvent)	[Reaction:R-BTA-202510] Activation of TAK1-TAB2 complex
(inferredTo)	[Reaction:R-HSA-202453] Auto-ubiquitination of TRAF6

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