Reactome | BMP:BMPRII:p-4S-BMPRI [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-BTA-201841] BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] - Bos taurus [Complex:R-BTA-201477] BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] - Bos taurus
consumedByEvent	[Reaction:R-BTA-201475] I-Smad competes with R-Smad1/5/8 for type I receptor - Bos taurus [Reaction:R-BTA-201648] An anchoring protein, Endofin, recruits R-Smad1/5/8 - Bos taurus [Reaction:R-BTA-201821] I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10351712
displayName	BMP:BMPRII:p-4S-BMPRI [plasma membrane]
hasComponent	[Complex:R-BTA-201463] BMP2 dimer [extracellular region] [Complex:R-BTA-201465] BMPRII dimer [plasma membrane] [Complex:R-BTA-201447] p-4S-BMPRI dimer [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-201426] BMP:BMPRII:p-4S-BMPRI [plasma membrane] - Homo sapiens
maxDepth	4
name	BMP:BMPRII:p-4S-BMPRI
producedByEvent	[Reaction:R-BTA-201443] Type II receptor phosphorylates type I receptor - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-201426
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-BTA-201821] I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated [Reaction:R-BTA-201475] I-Smad competes with R-Smad1/5/8 for type I receptor [Reaction:R-BTA-201648] An anchoring protein, Endofin, recruits R-Smad1/5/8
(hasComponent)	[Complex:R-BTA-201841] BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] [Complex:R-BTA-201446] BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] [Complex:R-BTA-201477] BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane]
(output)	[Reaction:R-BTA-201443] Type II receptor phosphorylates type I receptor
(inferredTo)	[Complex:R-HSA-201426] BMP:BMPRII:p-4S-BMPRI [plasma membrane]