Reactome | TRAF6 binds to p75NTR:NRIF

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TRAF6 binds to p75NTR:NRIF Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10349432
displayName	TRAF6 binds to p75NTR:NRIF
eventOf	[Pathway:R-BTA-205043] NRIF signals cell death from the nucleus - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-205112] gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 - Bos taurus [Reaction:R-BTA-193666] Active JNK moves to the nucleus and phosphorylates different transcription factors - Bos taurus
inferredFrom	[Reaction:R-HSA-193669] TRAF6 binds to p75NTR:NRIF - Homo sapiens
input	[Complex:R-BTA-205100] NGF ligand:p75NTR:NRIF [plasma membrane] [Complex:R-BTA-421373] TRAF6 homotrimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TRAF6 binds to p75NTR:NRIF
output	[Complex:R-BTA-204977] NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-193669
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-205043] NRIF signals cell death from the nucleus
(precedingEvent)	[Reaction:R-BTA-205112] gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 [Reaction:R-BTA-193666] Active JNK moves to the nucleus and phosphorylates different transcription factors
(inferredTo)	[Reaction:R-HSA-193669] TRAF6 binds to p75NTR:NRIF