Reactome | Oxidation of cholesterol to 22beta-hydroxycholesterol

Schema > Reaction > Entries

Oxidation of cholesterol to 22beta-hydroxycholesterol Show undefined attributes

catalystActivity	[CatalystActivity:10349250] cholesterol monooxygenase (side-chain-cleaving) activity of CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10349252
displayName	Oxidation of cholesterol to 22beta-hydroxycholesterol
eventOf	[Pathway:R-BTA-196108] Pregnenolone biosynthesis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-193065] Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol - Bos taurus
inferredFrom	[Reaction:R-HSA-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Homo sapiens
input	[SimpleEntity:R-ALL-193156] CHOL [mitochondrial inner membrane] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	Oxidation of cholesterol to 22beta-hydroxycholesterol cholesterol + NADPH + H+ => 22beta-hydroxycholesterol + NADP+ + H2O Oxidation of cholesterol
output	[SimpleEntity:R-ALL-193019] 22b-HCHOL [mitochondrial inner membrane] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent	[Reaction:R-BTA-196126] STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-193054
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-196108] Pregnenolone biosynthesis
(precedingEvent)	[Reaction:R-BTA-193065] Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol
(inferredTo)	[Reaction:R-HSA-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol

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