Reactome | 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al

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5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al Show undefined attributes

catalystActivity	[CatalystActivity:10349020] steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10349082
displayName	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
eventOf	[Pathway:R-BTA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-192054] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) - Bos taurus
inferredFrom	[Reaction:R-HSA-192042] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al - Homo sapiens
input	[SimpleEntity:R-ALL-192201] 5bCHOL3a,7a,12a,27-tetrol [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + NADP+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+
output	[SimpleEntity:R-ALL-191968] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
precedingEvent	[Reaction:R-BTA-191999] CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-192042
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(precedingEvent)	[Reaction:R-BTA-192054] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)
(inferredTo)	[Reaction:R-HSA-192042] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al

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