Reactome | Heme degradation

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Heme degradation Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10443922
displayName	Heme degradation
eventOf	[Pathway:R-BTA-189445] Metabolism of porphyrins - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9412] heme catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-189398] HMOX1 dimer, HMOX2 cleave heme - Bos taurus [Reaction:R-BTA-189384] BLVRA:Zn2+, BLVRB reduce BV to BIL - Bos taurus [Reaction:R-BTA-9661405] ABCC1 transports BIL from cytosol to extracellular region (blood) - Bos taurus [Reaction:R-BTA-9661432] BIL binds ALB - Bos taurus [BlackBoxEvent:R-BTA-9661425] BIL:ALB dissociates - Bos taurus [Reaction:R-BTA-9661397] SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) - Bos taurus [Reaction:R-BTA-9661723] SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) - Bos taurus [Reaction:R-BTA-9661799] SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) - Bos taurus [Reaction:R-BTA-9663511] BIL binds GSTA1, FABP1 - Bos taurus [BlackBoxEvent:R-BTA-9663492] BIL dissociates from GSTA1, FABP1 - Bos taurus [Reaction:R-BTA-5679041] ABCC2 transports BMG,BDG from cytosol to extracellular region - Bos taurus [Reaction:R-BTA-9661417] ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region - Bos taurus
inferredFrom	[Pathway:R-HSA-189483] Heme degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Heme degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-189483
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-189445] Metabolism of porphyrins
(inferredTo)	[Pathway:R-HSA-189483] Heme degradation

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