Reactome | SHP2 dephosphorylates Tyr 992 on EGFR

Schema > Reaction > Entries

SHP2 dephosphorylates Tyr 992 on EGFR Show undefined attributes

catalystActivity	[CatalystActivity:10347518] non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10347603
displayName	SHP2 dephosphorylates Tyr 992 on EGFR
eventOf	[Pathway:R-BTA-180292] GAB1 signalosome - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-177935] SHP2 dephosphorylates Tyr 992 on EGFR - Homo sapiens
input	[Complex:R-BTA-180269] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SHP2 dephosphorylates Tyr 992 on EGFR
output	[Complex:R-BTA-180326] EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-BTA-177944] Activation of SHP2 through the binding to phospho-Gab1 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-177935
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-180292] GAB1 signalosome
(inferredTo)	[Reaction:R-HSA-177935] SHP2 dephosphorylates Tyr 992 on EGFR

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