Reactome | PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS

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PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS Show undefined attributes

catalystActivity	[CatalystActivity:10346642] adenylylsulfate kinase activity of PAPSS1,2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10346644
displayName	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
eventOf	[Pathway:R-BTA-174362] Transport and metabolism of PAPS - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP - Bos taurus [Reaction:R-BTA-176604] taurolithocholate + PAPS => taurolithocholate sulfate + PAP - Bos taurus [Reaction:R-BTA-159358] SULT1A3,4 dimers sulfate DA to DAOS - Bos taurus [Reaction:R-BTA-176664] estrone + PAPS => estrone 3-sulfate + PAP - Bos taurus [Reaction:R-BTA-176474] 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP - Bos taurus [Reaction:R-BTA-176631] dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP - Bos taurus [Reaction:R-BTA-176588] lithocholate + PAPS => lithocholate sulfate + PAP - Bos taurus [Reaction:R-BTA-158860] SULT1A1 dimer sulfonates NHABP - Bos taurus [Reaction:R-BTA-176494] SULTs transfer (SO4)2- group to 27HCHOL - Bos taurus [Reaction:R-BTA-176521] beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP - Bos taurus [Reaction:R-BTA-176585] 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP - Bos taurus [Reaction:R-BTA-176517] SULTs transfer (SO4)2- group to PREG - Bos taurus [Reaction:R-BTA-158468] SULT1A1 dimer sulfonates PARA to PARA-SO4 - Bos taurus [Reaction:R-BTA-176646] p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP - Bos taurus [Reaction:R-BTA-176609] cholesterol + PAPS => cholesterol sulfate + PAP - Bos taurus [Reaction:R-BTA-158849] Phenol can form a sulfate conjugate - Bos taurus [Reaction:R-BTA-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP - Bos taurus
goBiologicalProcess	[GO_BiologicalProcess:80800] 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
inferredFrom	[Reaction:R-HSA-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Homo sapiens
input	[SimpleEntity:R-ALL-174370] APS [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS adenylyl sulfate (APS) + ATP => PAPS + ADP APS reacts with another ATP molecule to form PAPS
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-158471] PAPS [cytosol]
precedingEvent	[Reaction:R-BTA-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-174389
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-BTA-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP [Reaction:R-BTA-176604] taurolithocholate + PAPS => taurolithocholate sulfate + PAP [Reaction:R-BTA-159358] SULT1A3,4 dimers sulfate DA to DAOS [Reaction:R-BTA-176664] estrone + PAPS => estrone 3-sulfate + PAP [Reaction:R-BTA-176474] 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP [Reaction:R-BTA-176631] dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP [Reaction:R-BTA-176588] lithocholate + PAPS => lithocholate sulfate + PAP [Reaction:R-BTA-158860] SULT1A1 dimer sulfonates NHABP [Reaction:R-BTA-176494] SULTs transfer (SO4)2- group to 27HCHOL [Reaction:R-BTA-176521] beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP [Reaction:R-BTA-176585] 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP [Reaction:R-BTA-176517] SULTs transfer (SO4)2- group to PREG [Reaction:R-BTA-158468] SULT1A1 dimer sulfonates PARA to PARA-SO4 [Reaction:R-BTA-176646] p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP [Reaction:R-BTA-176609] cholesterol + PAPS => cholesterol sulfate + PAP [Reaction:R-BTA-158849] Phenol can form a sulfate conjugate [Reaction:R-BTA-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP
(hasEvent)	[Pathway:R-BTA-174362] Transport and metabolism of PAPS
(inferredTo)	[Reaction:R-HSA-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS

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