Reactome | Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling

Schema > BlackBoxEvent > Entries

Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling Show undefined attributes

catalystActivity	[CatalystActivity:10346171] ubiquitin-protein transferase activity of Nuclear ubiquitin ligase [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10346173
displayName	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling
eventOf	[Pathway:R-BTA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-173545] Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling - Homo sapiens
input	[DefinedSet:R-BTA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling
precedingEvent	[BlackBoxEvent:R-BTA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Bos taurus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-173545
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(inferredTo)	[BlackBoxEvent:R-HSA-173545] Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling

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