Reactome | PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10372780
displayName	PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane]
hasComponent	[Complex:R-BTA-1671652] PRLR ligands:PRLR:JAK2 dimer [plasma membrane] [EntityWithAccessionedSequence:R-BTA-1675482] SH2B1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-1675475] PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] - Homo sapiens
maxDepth	5
name	PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta
positivelyRegulates	[PositiveRegulation:10372783] Positive regulation by 'PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane]'
producedByEvent	[Reaction:R-BTA-1675473] SH2B binds JAK2 - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-1675475
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-BTA-1675473] SH2B binds JAK2
(regulator)	[PositiveRegulation:10372783] Positive regulation by 'PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane]'
(inferredTo)	[Complex:R-HSA-1675475] PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane]

Cite Us!