Reactome | S1P hydrolyzes SREBP1A,1C,2

Schema > Reaction > Entries

S1P hydrolyzes SREBP1A,1C,2 Show undefined attributes

catalystActivity	[CatalystActivity:10359516] serine-type endopeptidase activity of MBTPS1 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10380589
displayName	S1P hydrolyzes SREBP1A,1C,2
eventOf	[Pathway:R-BTA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1655851] S2P hydrolyzes SREBP1A,1C,2 - Bos taurus
inferredFrom	[Reaction:R-HSA-1655842] S1P hydrolyzes SREBP1A,1C,2 - Homo sapiens
input	[Complex:R-BTA-1655742] SREBP1A,1C,2:SCAP [Golgi membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	S1P hydrolyzes SREBP1A,1C,2 SKI-1 hydrolyzes SREBP1A,1C,2 S1P hydrolyzes SREBF1A,1C,2
output	[Complex:R-BTA-1655737] SCAP tetramer [Golgi membrane] 4 × [DefinedSet:R-BTA-1655726] SREBF1A,1C,2 cleaved by S1P [Golgi membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1655842
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF)
(precedingEvent)	[Reaction:R-BTA-1655851] S2P hydrolyzes SREBP1A,1C,2
(inferredTo)	[Reaction:R-HSA-1655842] S1P hydrolyzes SREBP1A,1C,2

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