Reactome | PXLP-K212-CTH cleaves L-Cystathionine

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PXLP-K212-CTH cleaves L-Cystathionine Show undefined attributes

catalystActivity	[CatalystActivity:10380242] cystathionine gamma-lyase activity of PXLP-K212-CTH tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10380244
displayName	PXLP-K212-CTH cleaves L-Cystathionine
eventOf	[Pathway:R-BTA-1614603] Cysteine formation from homocysteine - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1614645] CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine - Bos taurus [Reaction:R-BTA-1614614] Cysteine is degraded to pyruvate and H2S - Bos taurus [Reaction:R-BTA-1614591] Excess cysteine yields lanthionine and H2S - Bos taurus
inferredFrom	[Reaction:R-HSA-1614583] PXLP-K212-CTH cleaves L-Cystathionine - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1614518] L-Cystathionine [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-K212-CTH cleaves L-Cystathionine H2O + L,L-cystathionine => 2-oxobutanoate + L-cysteine + NH4(+)
output	[SimpleEntity:R-ALL-936714] 2OBUTA [cytosol] [SimpleEntity:R-ALL-111707] L-Cys [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol]
precedingEvent	[Reaction:R-BTA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1614583
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-BTA-1614645] CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine [Reaction:R-BTA-1614614] Cysteine is degraded to pyruvate and H2S [Reaction:R-BTA-1614591] Excess cysteine yields lanthionine and H2S
(hasEvent)	[Pathway:R-BTA-1614603] Cysteine formation from homocysteine
(inferredTo)	[Reaction:R-HSA-1614583] PXLP-K212-CTH cleaves L-Cystathionine

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