Reactome | ASAH1 hydrolyzes ceramide

Schema > Reaction > Entries

ASAH1 hydrolyzes ceramide Show undefined attributes

catalystActivity	[CatalystActivity:10379951] N-acylsphingosine amidohydrolase activity of ASAH1 [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10379955
displayName	ASAH1 hydrolyzes ceramide
eventOf	[Pathway:R-BTA-9840310] Glycosphingolipid catabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1606602] ASAH1 hydrolyzes ceramide - Homo sapiens
input	[SimpleEntity:R-ALL-1605673] CERA [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	ASAH1 hydrolyzes ceramide
output	[SimpleEntity:R-ALL-1861779] RCOO- [lysosomal lumen] [SimpleEntity:R-ALL-1606588] SPG [lysosomal lumen]
precedingEvent	[Reaction:R-BTA-1606564] GALC hydrolyzes GalCer - Bos taurus [Reaction:R-BTA-1605797] SMPD1 hydrolyzes SPHM - Bos taurus [Reaction:R-BTA-1605591] GBA1:SAPC hydrolyzes GlcCer - Bos taurus [BlackBoxEvent:R-BTA-9840334] PSAP is cleaved - Bos taurus
regulatedBy	[Requirement:10379956] Requirement by 'PSAP(405-486) [lysosomal lumen]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1606602
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9840310] Glycosphingolipid catabolism
(inferredTo)	[Reaction:R-HSA-1606602] ASAH1 hydrolyzes ceramide