Reactome | Activation of Matrix Metalloproteinases

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Activation of Matrix Metalloproteinases Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10445078
displayName	Activation of Matrix Metalloproteinases
eventOf	[Pathway:R-BTA-1474228] Degradation of the extracellular matrix - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:261789] extracellular matrix disassembly
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-1592316] Initial activation of proMMP1 - Bos taurus [Reaction:R-BTA-1602473] Autocatalytic activation of MMP1 - Bos taurus [Reaction:R-BTA-1592297] Full activation of MMP1 - Bos taurus [Reaction:R-BTA-1602454] proMMP9 binds TIMP1 - Bos taurus [Reaction:R-BTA-1592349] MMP14 (MT1-MMP) binds TIMP2 - Bos taurus [Reaction:R-BTA-1604350] MMP14:TIMP2 binds proMMP2 - Bos taurus [Reaction:R-BTA-1604359] Initial activation of proMMP2 by MMP1, 7 - Bos taurus [Reaction:R-BTA-1604360] Initial activation of proMMP2 by MMP14 - Bos taurus [Reaction:R-BTA-1592278] Autocatalytic activation of proMMP2 - Bos taurus [Reaction:R-BTA-1604368] Autocatalytic activation of bound proMMP2 - Bos taurus [Reaction:R-BTA-1592371] Initial activation of proMMP3 - Bos taurus [Reaction:R-BTA-1604731] Autocatalytic activation of MMP3 - Bos taurus [Reaction:R-BTA-1592362] Activation of proMMP7 by MMP3 - Bos taurus [Reaction:R-BTA-1604712] Initial activation of proMMP7 by trypsin - Bos taurus [Reaction:R-BTA-1604763] Autocatalytic activation of MMP7 - Bos taurus [BlackBoxEvent:R-BTA-1592398] Activation of proMMP8 - Bos taurus [Reaction:R-BTA-1592436] Initial activation of proMMP9 by MMPs - Bos taurus [Reaction:R-BTA-1604690] Activation of MMP9 intermediate form by MMPs - Bos taurus [Reaction:R-BTA-1604722] Activation of proMMP9 by proteases - Bos taurus [BlackBoxEvent:R-BTA-1602458] Activation of proMMP10 - Bos taurus [Reaction:R-BTA-1602484] Activation of proMMP11 by FURIN - Bos taurus [Reaction:R-BTA-1602488] Initial activation of proMMP13 by plasmin and trypsin - Bos taurus [Reaction:R-BTA-1604752] Initial activation of proMMP13 by MMP3 - Bos taurus [Reaction:R-BTA-1604741] Initial activation of proMMP13 by MMP14 (MT1-MMP) - Bos taurus [Reaction:R-BTA-1604732] Autocatalytic activation of proMMP13 - Bos taurus [Reaction:R-BTA-1602466] Activation of MT-MMPs by FURIN - Bos taurus [BlackBoxEvent:R-BTA-1605825] MT-MMPs are sorted to the plasma membrane - Bos taurus
inferredFrom	[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activation of Matrix Metalloproteinases
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-1592389
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1474228] Degradation of the extracellular matrix
(hasEncapsulatedEvent)	[Pathway:R-BTA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(inferredTo)	[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases

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